Myrciaria cauliflora extracts attenuating hyperlipidemia and obesity in vivo

Abstract

Obesity, the major reason causing the metabolic syndrome (MetS), leads to abnormal lipid metabolism, and also causes hyperlipidemia, morbidity and mortality in type 2 diabetes, cardiovascular and other diseases. These diseases often have increased insulin levels resulting from an insulin resistance lead to blood lipid abnormalities. Previously studies indicate that the polyphenols and anthocyanins ingredients have antioxidant, anti-arteriosclerosis, hypertension and diabetes suppression, hypolipidemic and tumor suppressor role. Therefore, this experiment will explore the preventive effect of extract from Myrciaria cauliflora (MCE) for the high-fat diet-induced obesity and dyslipidemia. In this study, we investigated the chemopreventive potential of the water extract from Myrciaria cauliflora (MCE) on the obesity male Wistar rat induced by lard oil for 10 weeks. The Serum biochemical parameters, body weight, were monitored every two weeks. After 10 weeks, the rats were sacrificed and the liver was assayed by HE stain and western blot. The results showed that dietary administration of MCE (0.5, 1, 1.5%) reduced the body weight of rat, serum biochemical parameters such as TG, TC, HDL-C, LDL-C, AST, ALT and lipid droplets in liver sections. Furthermore, MCE can also decrease the expression of lipid synthesis-related proteins by western blotting. These findings demonstrated that MCE prevented high-fat diet-induced high cholesterol and excess body fat, suggesting that MCE has a potentially protective effect in obesity-related and cardiovascular diseases.