Design and Evaluation of Matrix Type Transdermal Delivery System of Aceclofenac

Abstract

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) used for relief of pain and inflammation in osteoarthritis, rheuma-toid arthritis and ankylosing spondylitisad more. Through its analgesic and anti-inflammatory properties, aceclofenac provides symptomatic relief in a variety of painful conditions. Trandermal patch of aceclofenac fabricated with various polymers combina-tions of cellulose acetate (CA), ethyl cellulose (EC), polyvinyl pyrrollidone (PVP) and hydroxylpropyl methyl cellulose (HPMC). Transdermal patches were prepared by solvent evaporation technique. The prepared patches possessed satisfactory physicochemi-cal characteristics i.e. thickness, moisture content, drug content, moisture uptake, moisture loss, flatness, film thickness (mm), weight variation test (gm) and folding endurance number. In vitro drug release studies indicating that this highest release of poly-meric composition (EC: PVP) and (CA: PVP) in the ratio of 1:4 were found to be best choice for effective combination for manu-facturing transdermal patches of aceclofenac to get higher rate of drug release to achieve therapeutic concentration. Due to highly hydrophilic nature of PVP it absorbs water and swells resulting the more release of the drug from the film. So hydrophilic polymer shows higher drug release rate.