The role of decreased levels of antimicrobian peptides in progression of chronic renal insufficiency

Abstract

Antimicrobial peptides (AMPs) are gaining popularity as better substitute to antibiotics. These peptides are shown to be active against several bacteria, fungi, viruses, protozoa and cancerous cells. Understanding the role of primary structure of AMPs in their specificity and activity is essential for their rational design as drugs. The aim of present study was to estimate the level of defensines in peripheral blood of patients with chronic and progression of renal insufficiency