Role of Vitamin D in Breast Cancer Prevention – A Review

Abstract

Several recent epidemiological and experimental studies have suggested that decrease vitamin D intake is associated with mammary gland carcinogenesis. Recent studies have begun to evaluate a possible role of increase dietary vitamin D in reducing the risk of breast cancer. Studies show that their anticarcinogenic effect due to their participation in regulating cellular proliferation, terminal differentiation, angiogenesis, and apoptosis in normal and malignant breast cells. Recent studies show that vitamin D Receptor have been found in up to 80% of breast cancers, and human with vitamin D receptor positive tumors had longer disease free survival than those with receptor negative tumors.