NOVEL DRUG DELIVERY SYSTEMS OF HERBAL CONSTITUENTS USED IN ACNE

Abstract

Novel technologies have been developed advanced research for drug delivery systems. Plant based medicines are used from ancient time for treatment of diseases. Drug delivery system is very important to decide the administration of drug, to overcome the disadvantages of traditional or other delivery system. The main goal for making the herbal NDDS system is to minimize the drug degradation taken by oral route of drug and   harmful side effects and increases the bioavailability. The herbal NDDS delivery system is to make the drug control release as well as sustain drug action, at a predetermined rate, to maintain a relatively constant, effective drug level in the body with minimization of undesirable side effects. The main reason behind for the formulation of NDDS is to make sustain and control release of drug for better therapeutic effect. The method by which a drug is delivered can have a significant effect on its efficacy. Some drugs have an optimum concentration range within which maximum benefit is derived, and concentrations above or below this range can be toxic or produce no therapeutic benefit at herbal novel drug delivery system is better than synthetic NDDS .Because of their less toxicity and better therapeutic action. In NDDS we knows its predetermination release rate, thus it reduces toxicity by decreasing the dose frequency. Now a day’s liposome, ethosome, phytosomes, emulsions, microsphere, solid lipid nanoparticles, niosomes, hydrogel of herbal formulation has enhanced the therapeutic effects of plant extracts.

Keywords – plant constituents, skin disorder, NDDS, toxicity.