Formulation, Development and Evaluation of Multiple Unit Pellet System Aspirin Matrix Tablet

Abstract

The sustained released pellets containing Aspirin was prepared using an Fluidized bed processor technique. Amount of Microcrystalline cellulose (Avicel pH102, Hypromellose 6 cps and Eudragit RS, Eudragit L were taken as the formulation variables for optimizing to keep round shape of pellets and percentage release of drug. The pellets were evaluated for Physical characterization, Assay, Sizing, Aspect ratio, density, SEM, In-vitro drug release and Binder’s concentration tends to very effective pellets shape and size. Percentage release of drug intended to very non-linear with polymer type and percentage of coating on the pellets.