Formulation and Evaluation of Nimesulide Sublimated Mouth Dissolving Tablets.

Abstract

 

The goal of the present investigation was to formulate and evaluate Mouth dissolving tablets (MDT) of Nimeulide which is a COX II inhibitor and one of the potent NSAIDs, used frequently in case of arthritis, spondalytis, dysmennorohea, etc. Crospovidone, Sodium starch glycolate, microcrystalline cellulose were used as superdisintegrating agents and camphor as a sublimating agent in formulating MDTs. Three processes involved in the manufacturing of MDTs were- direct compression, sublimation technique I and sublimation technique II. The FTIR spectra of drug and different polymers showed no shift in peak, hence no interaction.Preformulation studies of drug and excipients were carried out and showed satisfactory results. The MDTs were evaluated for their hardness, friability, water absorption ratio, disintegration time and in-vitro dissolution. The in-vitro release study showed quick and maximum drug release about 86.91% within 30 min from formula NSS5.Accelerated stability studies were carried out at 40°C and 75 % RH for optimized formulation  NSS5. The post FTIR spectra showed no shift in peaks.From the disintegrating time data, release study and stability studies formulation NSS5 showed satisfactory results. Hence this study showed that sublimation is the best technique to formulate MDTs.