Review Article: Causes of Recurrent of Abortion

Abstract

Reoccurrence of Spontaneous abortion (RSA) in pregnant women is frequently encountered complications with no apparent cause.  Multiple environmental and genetic factors had been studied that included; hereditary factors, hematologic and immunologic factors, endocrine factors andlifestyle factors.The key aspects of chromosomal abnormalities in RSA women were reviewed.  The central theme of the hematologic and immunologic factors focused on  studiesthat associated RSA to infection, clot formation, pro-inflammatory and anti-inflammatory cytokines as well as their genes polymorphism. The factors that underlie hormonal abnormalities and occupational hazards as they pertain to RSA were also reviewed. To conclude genes polymorphisms of inflammatory and anti-inflammatory cytokines seem promising to establish causal molecular relations with RSA.