Role of C - reactive protein (CRP) as a Marker of an Acute Phase Response in Case Of Diabetes Mellitus: A Mini Review

Abstract

Diabetes Mellitus is one of the most common major public health problems having worldwide distribution. Depending on the etiology of diabetes mellitus, factors contributing to hyperglycemia may include; reduced insulin secretion, decreased glucose usage and increased glucose production. Recently, there in increasing evidence that an ongoing cytokine induced acute phase response which is sometimes called low grade inflammation, but part of a widespread activation of the innate immune system, is closely involved in the pathogenesis of type 2 diabetes mellitus and associated complications such as dyslipidemia and atherosclerosis. Elevated circulatory inflammatory markers such as C-reactive protein and interleukin-6 predict the development of type 2 Diabetes mellitus and several drugs with anti-inflammatory properties both lower both acute phase reactants and glycemia and possible decrease the risk of developing type 2 diabetes mellitus. In this mini review article, we aimed to systematically review the role of C-reactive protein (CRP) as inflammatory marker with increased risk of type 2 diabetes as well the relation with type 1 diabetes