Discovery of Some Potential Acetylcholinesterase Inhibitors using in Silico Docking Studies

Abstract

Alzheimer's disease (AD) is the most common cause of de- mentia characterized by progressive cognitive impairment in the elderly people. The most dramatic abnormalities are those of the cholinergic system. Acetylcholinesterase (AChE) plays a key role in the regulation of the cholinergic system, and hence, inhibition of AChE has emerged as one of the most promising strategies for the treatment of AD.