Formulation and In-Vitro Evaluation of Buccoadhesive Tablets of Antiemetic Drug

Abstract

The aim of this study was to design and develop buccoadhesive formulation using the combination of two natural gum i.e. Almond gum (AG) and Moring gum (MG) with Ondansetron hydrochloride as an antiemetic model drug. Direct compression technique was employed for the preparation of buccoadhesive tablets. All formulations were tested for pre and post-compressional parameters to study the effect of formulation variables on mucoadhesive strength and in vitro drug release profile.

Surface pH study of tablets indicated that the all formulations are suitable for buccal environment. The hardness, friability, weight variation, drug content, surface pH, mucoadhesive strength , in vitro release were uniform and reproducible. However, the AG and MG markedly affected the mucoadhesion strength and the release profile. Mucoadhesive strength and drug release was found to be a function of amount of polymers. The formulation variables were found to be significant for mucoadhesion and release properties (P < 0.05). Lower amount of both polymers shows higher drug release and formulations T1-T3 eroded during release study before stipulated study period. The investigation results clearly indicated that, the combination of AG and MG has sufficient mucoadhesive property for buccal application.