Identification of the Genetic Mutations Associated With INH Mono Resistance in Mycobacterium Tuberculosis Isolates From Patients in a Tertiary Care Centre

Abstract

Tuberculosis remains a significant public health issue worldwide, with India having one of the highest burden of disease. Isoniazid (INH) is a cornerstone drug in the treatment of TB. However, INH mono resistance poses a considerable challenge to effective TB control. Understanding genetic mutations responsible for INH resistance is crucial for the development of diagnostic tools and treatment strategies. Our study aims to identify and characterize the genetic mutations associated with INH mono resistance in Mycobacterium tuberculosis isolates from patients in Goa. Also, our study aims to evaluate whether patients developing isoniazid mono resistant tuberculosis occurs more in patients with anti-TB treatment in the past.