Effects of Oral Administration of Aqueous Extract of Tridax Procumbens on Body Organs and Hematological Parameters

Abstract

The study profiled the effects of oral administration of three non-therapeutic doses (400,632 and 1000mg/kg body weight) of aqueous extract of Tridax procumbens on body organs and hematological parameters on male Swiss albino mice. The experimental mice were housed at room temperature with 12hours/12hours darkness photoperiod, provided with rodent standard pellets and water ad libitum. Hematological profile and organs toxicity assay were executed using standard laboratory procedures. The result demonstrated a significant (Ï≤0.05) decrease in the weekly weight gain by the experimental mice, relative to the control mice. The normalized weight of the organs remained significantly unaffected except the lungs which were significantly increased at 400mg/kg body weight, relative to the control. Moreover, there was no significant change in the levels of the hematological indices except the monocytes, where a significant increase was observed at 632mg/kg body weight, relative to the control. The plant extract demonstrated only very mild toxicity and hence recommended for use where beneficial pharmacological activity of the plant extract has been established.