Antibacterial potential and HPLC analysis of dried roots of chlorophytum borivilianum l. (safed musli)

Abstract

Emergence of microbial resistance is the one of the major problem nowadays; thus there have been tremendous efforts towards finding new chemicals, specifically herbals, for the development of new antimicrobial drugs. Chlorophytum borivilianum Linn. is selected to evaluate the antibacterial potential by agar well diffusion assay against a total of six bacterial strains. Active extracts were further subjected to determine their MICs followed by their phytochemical analysis. The current study indicated that almost all the extracts evaluated showed variable degree of inhibition zones against different bacterial species except hexane extract which was found completely inactive. Other organic extracts viz., ethanol, methanol and ethyl acetate were found to have significant activity against all test bacteria except Escherichia coli, which was observed completely resistant to all the extracts. Methanol extract was found comparatively more effective Organic extracts provided more potent antibacterial activity as compared to aqueous extracts. Gram-positive bacteria were found more sensitive than Gram-negative bacteria. The study promises an interesting future for designing potentially active antibacterial agents from Chlorophytum borivilianum Linn.