Effects of the Methanol Leaf Extract Of Chromolaena Odorata on Blood Lipids and the Histology of the Kidney in Salmonella Typhi Infected Wistar Rats

Abstract

Infection with Salmonella typhi, the causative agent of typhoid fever is said to be associated with dyslipidemia. This study evaluated the effects of Chromolaena odorata on the lipid profile and histology of the kidneys in Salmonella typhi infected Wistar rats. The animals were divided into six groups: group 1 was normal control, group 2 was infected with Salmonella typhi without treatment, groups 3, 4 and 5 were Salmonella typhi infected and treated with 100mg/kg, 200mg/kg and 400mg/kg of the extract, respectively, and group 6 was infected and treated with 500mg/70kg of ciprofloxacin. The animals were inoculated with a single infectious dose of Salmonella typhi bacteria and were subsequently, treated with graded doses of the methanol leaf extract of Chromolaena odorata and 500mg/70kg dose of ciprofloxacin for a period of seventeen days, when the animals were confirmed infected. The animals were humanely sacrificed using diethyl ether anesthesia and blood sample was collected for lipid profile investigation and the kidneys were harvested for histological examination. Chromolaena odorata administration reversed the dyslipidemia and histological changes induced by Salmonella typhi.