Design and Evaluation of Self-Emulsifying Drug Delivery System (SEDDS)

Abstract

The aim of the present work was to prepare SEDDS to sustain the drug release. Various oils, surfactants and co-surfactants were screened for their suitability in the formulation of SEDDS. Based on the solubility studies, Oleic acid was selected as oil phase, Tween20 as a surfactant, PEG 600 as a Co - surfactant. Pseudo ternary phase diagrams were constructed to determine the nano emulsion area for each formulation. SEDDS can be effectively formulated by adsorption technique. SEDDS could sustain the drug release. A nano emulsion gel was developed to enhance bioavailability of the drug. The in vitro drug release of SEDDS was sustained (for 24 hours) when compared to marketed formulation. Pharmacodynamic studies performed by paw volume method indicated significant (p< 0.05) inhibition in paw edema (75%) for the test formulation after 4hours as compared to the standard formulation (56%.).